The final tribute of the evening went to Irish band U2 which, with members Bono, The Edge, Adam Clayton and Larry Mullen Jr., has won 22 Grammy Awards and was inducted into the Rock and Roll Hall of Fame in 2005.
Sacha Baron Cohen, playing his alter ego character Borat, quipped on stage that he was looking for former President Donald Trump and made reference to Kanye West's recent problematic behaviour.
Vedder performed "Elevation" and "One," while Ukrainian singer Jamala joined Carlile and others to perform "Walk On."
"At a moment when there’s too much hate, too much anger, too much division here in America and, quite frankly, around the world, we have to remember today, as their song goes, 'We’re one, but we’re not the same. We get to carry each other,'” Biden said at the White House, referencing a U2 lyric.
The Kennedy Center Honors show will be broadcast on CBS on Dec. 28.